What does the mineralocorticoid receptor do?

Mineralocorticoid receptors (MR) bind both mineralocorticoids and glucocorticoids with high affinity (deoxycorticosterone = corticosterone >/= aldosterone = cortisol), and are found in both Na(+) transporting epithelia (e.g. kidney, colon) and nonepithelial tissues (e.g. heart, brain).

What type of receptor does aldosterone bind to?

Aldosterone and Mineralocorticoid Receptors The mineralocorticoid receptor binds both aldosterone and cortisol with equal affinity.

Can aldosterone bind glucocorticoid receptor?

Lower-affinity aldosterone-binding sites are termed glucocorticoid receptors. Another mechanism that serves to alter the balance of CORT and aldosterone binding to receptors is the activity of 11β-hydroxysteroid dehydrogenase, which, in the rat kidney, rapidly oxidizes CORT to inactive metabolites.

Is aldosterone a mineralocorticoid receptor?

Aldosterone is a steroid hormone with mineralocorticoid activity, produced primarily in the glomerular zone of the adrenal cortex.

What are the mineralocorticoid hormones?

Mineralocorticoids are a class of steroid hormones that influence salt and water balance. The primary mineralocorticoid is aldosterone, but other endogenous hormones such as progesterone and deoxycorticosterone have mineralocorticoid function.

What happens when mineralocorticoid receptor is activated?

In this setting, mineralocorticoid receptor (MR) activation in endothelial cells can contribute to amplify cardiovascular adverse outcomes, exacerbating vascular stiffness through the induction of augmented ROS production, vascular inflammation and collagen deposition, finally leading to endothelial dysfunction and …

Where are the aldosterone receptors?

The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31. 1-31.2.

Where are aldosterone receptors located in kidney?

Specific nuclear binding sites are localized in the distal parts of the nephron, with some variations according to the steroid hormone considered: target cells for aldosterone are located in the distal tubule and cortical collecting duct, glucocorticoid receptors are present in all distal segments, whereas those of 1- …

Is aldosterone a nuclear receptor?

Introduction. The aldosterone receptor, also referred to as the mineralocorticoid receptor (MR), is a member of the nuclear receptor superfamily (NR3C2) that acts as a ligand-dependent transcription factor mediating mineralocorticoid effects on a large variety of target cells.