What is FnBPA?
What is FnBPA?
Fibronectin binding protein A (FnBPA) is a Staphylococcus aureus MSCRAMM cell surface-bound protein that binds to both fibronectin and fibrinogen. It is an adhesin which enables Staphylococcus aureus (S.
Where is fibronectin located?
Fibronectin is located on the apical and basal cell surfaces and between the cells in the undifferentiated regions of the colony (outer edge and stratified region). It seems to run parallel to intracellular microfilament bundles and to be associated with them across the cell membrane.
What type of protein is fibronectin?
glycoprotein
Fibronectin is a glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins. It has a high molecular weight of about 440 kDa. Fibronectin binds the cell to the extracellular matrix and organizes it. It can bind collagen, fibrin, and proteoglycans.
Where is fibronectin made?
soluble plasma fibronectin (formerly called “cold-insoluble globulin”, or CIg) is a major protein component of blood plasma (300 μg/ml) and is produced in the liver by hepatocytes. insoluble cellular fibronectin is a major component of the extracellular matrix.
What does FnbpA stand for?
Fibronectin binding protein A. Fibronectin binding protein A (FnBPA) is a Staphylococcus aureus MSCRAMM cell surface-bound protein that binds to both fibronectin and fibrinogen.
How does FnbpA bind with fibrinogen?
FnBPA also binds with fibrinogen (Fg) by using a unique ligand binding mechanism called dock, lock and latch. Nanoparticles, especially nanosilver particles have been widely used in a variety of biomedical applications which includes disease diagnosis and treatment, drug delivery and implanted medical device coating.
What is the function of FnBP?
The FnBP is involved in adherence to a wide range of mammalian cells and is hence implicated in various infections. It is implicated in the pathogenesis of osteomyelitis, and is the predominant adhesin for adherence to osteoblasts, a cell type present in large quantities within bone.
What is fibrinogen and fibronectin binding protein a?
Fibronectin binding protein A (FnBPA) is a Staphylococcus aureus MSCRAMM cell surface-bound protein that binds to both fibronectin and fibrinogen . It is an adhesin which enables Staphylococcus aureus ( S. aureus) to adhere to host cells of another organism, and an invasin facilitating its internalisation into these cells.